标签归档：peprotech

Peprotech重组人TGF-β1细胞因子Recombinant Human TGF-β1 （mammalian derived）100-21

发表于由

Peprotech重组人TGF-β1细胞因子Recombinant Human TGF-β1 （mammalian derived）

  • 产品型号：  100-21
  • 简单描述
  • Recombinant Human TGF-β1 (mammalian derived)重组人TGF-β1细胞因子，详细产品信息请
详细介绍

 

Recombinant Human TGF-β1 （mammalian derived）

Catalog Number:
100-21
Synonyms:
Transforming Growth Factor-β1, Differentiation inhibiting factor, Cartilage-inducing factor
Description:
The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-β1 is the most abundant isoform secreted by almost every cell type. It was originally identified for its ability to induce phenotypic transformation of fibroblasts and recently it has been implicated in the formation of skin tumors. Human TGF-β1 is a 25.0 kDa protein with each subunit containing 112 amino acid residues, linked by a single disulfide bond.
AA Sequence:
ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS
Source:
HEK293 cells
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
The ED50 was determined by TGF-beta1’s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.
 
 
 
 
Cross Reactivity:
Chicken, Cow, Dog, Frog, Monkey, Mouse, Pig, Rabbit, Rat, Human, Mink, Donkey, N/A
Research Interests:
Peprotech重组人TGF-β1细胞因子Recombinant Human TGF-β1 （mammalian derived）100-21 Angiogenesis/ Cardiovascular Peprotech重组人TGF-β1细胞因子Recombinant Human TGF-β1 （mammalian derived）100-21 Apoptosis
Peprotech重组人TGF-β1细胞因子Recombinant Human TGF-β1 （mammalian derived）100-21 Cancer Peprotech重组人TGF-β1细胞因子Recombinant Human TGF-β1 （mammalian derived）100-21 Immune System
Peprotech重组人TGF-β1细胞因子Recombinant Human TGF-β1 （mammalian derived）100-21 Inflammation Peprotech重组人TGF-β1细胞因子Recombinant Human TGF-β1 （mammalian derived）100-21 Proliferation
Peprotech重组人TGF-β1细胞因子Recombinant Human TGF-β1 （mammalian derived）100-21 Stem Cells & Differentiation Peprotech重组人TGF-β1细胞因子Recombinant Human TGF-β1 （mammalian derived）100-21 TGF-β Superfamily
Peprotech重组人TGF-β1细胞因子Recombinant Human TGF-β1 （mammalian derived）100-21 Wound Healing Peprotech重组人TGF-β1细胞因子Recombinant Human TGF-β1 （mammalian derived）100-21 Allergy
 
 
Country of Origin:
USA

Peprotech重组人TGF-β1细胞因子Recombinant Human TGF-β1 （mammalian derived）100-21

发表于由

Peprotech重组人TGF-β1细胞因子Recombinant Human TGF-β1 （mammalian derived）

  • 产品型号：  100-21
  • 简单描述
  • Recombinant Human TGF-β1 (mammalian derived)重组人TGF-β1细胞因子，详细产品信息请
详细介绍

 

Recombinant Human TGF-β1 （mammalian derived）

Catalog Number:
100-21
Synonyms:
Transforming Growth Factor-β1, Differentiation inhibiting factor, Cartilage-inducing factor
Description:
The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-β1 is the most abundant isoform secreted by almost every cell type. It was originally identified for its ability to induce phenotypic transformation of fibroblasts and recently it has been implicated in the formation of skin tumors. Human TGF-β1 is a 25.0 kDa protein with each subunit containing 112 amino acid residues, linked by a single disulfide bond.
AA Sequence:
ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS
Source:
HEK293 cells
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
The ED50 was determined by TGF-beta1’s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.
 
 
 
 
Cross Reactivity:
Chicken, Cow, Dog, Frog, Monkey, Mouse, Pig, Rabbit, Rat, Human, Mink, Donkey, N/A
Research Interests:
Peprotech重组人TGF-β1细胞因子Recombinant Human TGF-β1 （mammalian derived）100-21 Angiogenesis/ Cardiovascular Peprotech重组人TGF-β1细胞因子Recombinant Human TGF-β1 （mammalian derived）100-21 Apoptosis
Peprotech重组人TGF-β1细胞因子Recombinant Human TGF-β1 （mammalian derived）100-21 Cancer Peprotech重组人TGF-β1细胞因子Recombinant Human TGF-β1 （mammalian derived）100-21 Immune System
Peprotech重组人TGF-β1细胞因子Recombinant Human TGF-β1 （mammalian derived）100-21 Inflammation Peprotech重组人TGF-β1细胞因子Recombinant Human TGF-β1 （mammalian derived）100-21 Proliferation
Peprotech重组人TGF-β1细胞因子Recombinant Human TGF-β1 （mammalian derived）100-21 Stem Cells & Differentiation Peprotech重组人TGF-β1细胞因子Recombinant Human TGF-β1 （mammalian derived）100-21 TGF-β Superfamily
Peprotech重组人TGF-β1细胞因子Recombinant Human TGF-β1 （mammalian derived）100-21 Wound Healing Peprotech重组人TGF-β1细胞因子Recombinant Human TGF-β1 （mammalian derived）100-21 Allergy
 
 
Country of Origin:
USA