检测样本量

（稀释样本）

AKRIE-010

633-02899

Lbis^® IgE Rat ELISA Kit  
大鼠免疫球蛋白E（IgE）ELISA试剂盒

Lbis^® KLH(TDAR)-Rat IgG ELISA KIT
血蓝蛋白（KLH）（T细胞依赖性抗原）

大鼠免疫球蛋白G（IgG） ELISA试剂盒 (＊１)

Lbis^® KLH(TDAR)-Rat IgM ELISA KIT
血蓝蛋白（KLH）（T细胞依赖性抗原）

大鼠免疫球蛋白M（IgM） ELISA试剂盒 (＊２)

Lbis^® OVA-IgE Mouse
小鼠卵清蛋白特异性免疫球蛋白E

（OVA-IgE）ELISA试剂盒 

Lbis^® OVA-IgG1 Mouse
小鼠卵清蛋白特异性免疫球蛋白G1

（OVA-IgG1）ELISA试剂盒

AKRSD-051
630-02701

Lbis^® Rheumatoid Factor IgG-Mouse ELISA Kit
小鼠免疫球蛋白G（IgG）

类风湿因子 ELISA试剂盒

Lbis^® Rheumatoid Factor IgM-Mouse ELISA Kit
小鼠免疫球蛋白M（IgM)

类风湿因子 ELISA试剂盒

 1.

Inhibitory Effect of Carnosol on Phthalic Anhydride-Induced Atopic Dermatitis via Inhibition of STAT3. Lee DY, Hwang CJ, Choi JY, Park MH, Song MJ, Oh KW, Son DJ, Lee SH, Han SB, Hong JT. Biomol Ther (Seoul). 2017 Sep 1;25(5):535-544.

 2.

Effects of aqueous extract from red Liriope platyphylla on phthalic-anhydride-induced atopic dermatitis in Interleukin-4/Luciferase/Consensus non-coding sequence-1 transgenic mice evaluated in terms of luciferase signal and general phenotype biomarkers. Kwak MH, Kim JE, Go J, Son HJ, Lee HS, Hong JT, Hwang DY. Journal of Traditional Chinese Medicine, Vol.37, Issue 4, Aug 2017, p475-485

 3.

Oral administration of freeze-dried powders of honey bee larvae inhibits the development of atopic dermatitis-like skin lesions in NC/Nga mice. Kageyama M, Xing G, Li K, Zhang Z, Sugiyama A. Personalized Medicine Universe, Vol. 6, July 2017, Pages 22-27.

 4.

Differential Nitric Oxide-Derived Protein Modifications of Flavin-Containing Monooxygenases in Type 1 Allergic Mice. Tanino T, Bando T, Komada A, Nojiri Y, Okada Y, Ueda Y, and Sakurai E. Drug Metabolism and Disposition  July 31, 2017,  dmd.117.076570;

 5.

Simultaneously increased expression of glucocorticoid‑induced tumor necrosis factor receptor and its ligand contributes to increased interleukin‑5/13‑producing group 2 innate lymphocytes in murine asthma. Zhang M, Wan J, Xu Y, Zhang D, Peng J, Qi C, Guo Q, Xia S, Su Z, Wang S, Xu H. Mol Med Rep. 2017 Jun;15(6):4291-4299.

 6.

Transgenic rat model of childhood-onset dermatitis by overexpressing telomerase reverse transcriptase (TERT). Kaneko R, Sato A, Hamada S, Yagi T, Ohsawa I, Ohtsuki M, Kobayashi E, Hirabayashi M, Murakami T. Transgenic Res. 2016 Aug;25(4):413-24.

 7.

Effects of sublingual immunotherapy in a murine asthma model sensitized by intranasal administration of house dust mite extracts. Shima K, Koya T, Tsukioka K, Sakagami T, Hasegawa T, Fukano C, Ohashi-Doi K, Watanabe S, Suzuki E, Kikuchi T. Allergol Int. 2016 Jul 8.

 8.

Therapeutic effect of tyndallized Lactobacillus rhamnosus IDCC 3201 on atopic dermatitis mediated by down-regulation of immunoglobulin E in NC/Nga mice. Lee SH, Yoon JM, Kim YH, Jeong DG, Park S, Kang DJ. Microbiol Immunol. 2016 Jul;60(7):468-76.

 9.

Gain-switched 311-nm Ti:Sapphire laser might be a potential treatment modality for atopic dermatitis.. Choi SY, Oh CT, Kwon TR, Kwon HJ, Choi EJ, Jang YJ, Kim HS, Chu H, Mun SK, Kim MN, Kim BJ. Lasers Med Sci. 2016 Jul 9.

10.

Perilla leaf extract prevents atopic dermatitis induced by an extract of Dermatophagoides farinae in NC/Nga mice. Komatsu KI, Takanari J, Maeda T, Kitadate K, Sato T, Mihara Y, Uehara K, Wakame K. Asian Pac J Allergy Immunol. 2016 Mar 20.

11.

Functional polysaccharides from Grifola frondosa aqueous extract inhibit atopic dermatitis-like skin lesions in NC/Nga mice. Park HS, Hwang YH, Kim MK, Hong GE, Lee HJ, Nagappan A, Yumnam S, Kim EH, Heo JD, Lee SJ, Won CK, Kim GS. Biosci Biotechnol Biochem. Vol.79(1), p147-54, 2015.

12.

Inhibitory effect of 5,6-dihydroergosteol-glucoside on atopic dermatitis-like skin lesions via suppression of NF-κB and STAT activation. Jung M, Lee TH, Oh HJ, Kim H, Son Y, Lee EH, Kim J. J Dermatol Sci. 2015

13.

Immunopotentiator from Pantoea agglomerans Prevents Atopic Dermatitis Induced by Dermatophagoides farinae Extract in NC/Nga Mouse. Wakame K, Komatsu K, Inagawa H, Nishizawa T. Anticancer Res. Vol.35(8), p4501-8, Aug 2015.

14.

Solanum tuberosum L. cv Jayoung Epidermis Extract Inhibits Mite Antigen-Induced Atopic Dermatitis in NC/Nga Mice by Regulating the Th1/Th2 Balance and Expression of Filaggrin. Yang G, Cheon SY, Chung KS, Lee SJ, Hong CH, Lee KT, Jang DS, Jeong JC, Kwon OK, Nam JH, An HJ. J Med Food. 2015 Jun 23.

15.

Gamisasangja-tang suppresses pruritus and atopic skin inflammation in the NC/Nga murine model of atopic dermatitis. Park BK, Park YC, Jung IC, Kim SH, Choi JJ, Do M, Kim SY, Jin M. J Ethnopharmacol. 2015 Feb 23.

16.

Bacillus subtilis KCTC 11782BP-produced alginate oligosaccharide effectively suppresses asthma via T-helper cell type 2-related cytokines. Bang MA, Seo JH, Seo JW, Jo GH, Jung SK, Yu R, Park DH, Park SJ. PLoS One. 2015 Feb 6;10(2):e0117524.

17.

Effect of the hand antiseptic agents benzalkonium chloride, povidone-iodine, ethanol, and chlorhexidine gluconate on atopic dermatitis in NC/Nga mice. Sadakane K, Ichinose T. Int J Med Sci. Vol.5;12(2), p116-25, Jan 2015.

18.

Effects of oral administration of di-(2-ethylhexyl) and diisononyl phthalates on atopic dermatitis in NC/Nga mice. Sadakane K., Ichinose T., Takano H., Yanagisawa R. and Koike E. Immunopharmacology and Immunotoxicology, Vol.36(1), p61-69, Feb 2014.

19.

Oral Administration of SSC201, a Medicinal Herbal Formula, Suppresses Atopic Dermatitis-Like Skin Lesions. Kyung P., Chun P., Chul J., Hyung K., Eun C., Sunyoung P., June C. and Mirim J. Journal of Medicinal Food, 2014.

20.

Effect of Allergen Sensitization on External Root Resorption. Murata N., Ioi H., Ouchi M., Takao T., Oida H., Aijima R., Yamaza T., Kido MA. JDR, Vol.92(7), p641-647, Jul 2013.

21.

Quantitative evaluation of therapeutic effect of Liriope platyphylla on phthalic anhydride-induced atopic dermatitis in IL-4/Luc/CNS-1 Tg mice. M.H.Kwak, J.E.Kim, I.S.Hwang, Y.J.Lee, B.S.An, J.T.Hong, S.H.Lee, D.Y.Hwang. Journal of Ethnopharmacology, Vol.148(3), p880-889, Jul 2013.

22.

Lack of both α2-antiplasmin and plasminogen activator inhibitor type-1 induces high IgE production. K.Okada, S.Ueshima, N.Kawao, M.Yano, Y.Tamura, M.Tanaka, A.Sakamoto, M.Hatano, M.Arima, S.Miyata, N.Nagai, T.Tokuhisa, O.Matsuo. Life Sciences, Vol.93(2-3), p89-95, Jul 2013.

23.

Therapeutic effects of fermented soycrud on phenotypes of atopic dermatitis induced by phthalic anhydride. Sung J-E., Kwak M-H., Kim J-E., Lee Y-J., Kim R-U., Kim E-A., Lee G-Y., Kim D-S. and Hwang D-Y. Lab Anim Res, Vol.29(2), p103-112, Jun 2013.

24.

Water-soluble chitosan and herbal honey compound alleviates atopic dermatitis-like lesions in NC/Nga mice. C.Choi, W.-S.Kim, Y.H.Park, S.-C.Park, M.-K.Jang, J.-W.Nah. Journal of Industrial and Engineering Chemistry, May 2013.

25.

Interleukin-17/T-helper 17 cells in an atopic dermatitis mouse model aggravate orthodontic root resorption in dental pulp. M.Shimizu, M.Yamaguchi, S.Fujita, T.Utsunomiya, H.Yamamoto, K.Kasai. European Journal of Oral Sciences, Vol.121(2), p101-110, Apr 2013.

26.

Water-soluble chitosan and herbal honey compound alleviates atopic dermatitis-like lesions in NC/Nga mice. Choi C., Kim W-S., Park YH., Park S-C., Jang M-K., Nah J-W. Journal of Industrial and Engineering Chemistry, Vol.20(2), p499-504, Mar 2014.

27.

Indirubin, a purple 3,2- bisindole, inhibited allergic contact dermatitis via regulating T helper (Th)-mediated immune system in DNCB-induced model. Kim M H, Choi Y Y, Yang G, Cho I-H, Nam D, Yang W M. Journal of Ethnopharmacology, Vol.145(1), p214-219, Jan 2013.

28.

Effects of Catalpa ovata stem bark on atopic dermatitis-like skin lesions in NC/Nga mice. Yang G, Choi C-H, Lee K, Lee M, Ham I, Choi H-Y. Journal of Ethnopharmacology, Vol.145(2), p416-423, Jan 2013.

29.

Interleukin 33 Is Induced by Tumor Necrosis Factor α and Interferon γ in Keratinocytes and Contributes to Allergic Contact Dermatitis. Taniguchi K., Yamamoto S., Hitomi E., Inada Y., Suyama Y., Sugioka T., Hamasaki Y. J Investig Allergol Clin Immunol, Vol.23(6), p428-434, 2013.

30.

Organic Chemicals in Diesel Exhaust Particles Enhance Picryl Chloride-Induced Atopic Dermatitis in NC/Nga Mice. Sadakane K., Ichinose T., Takano H., Yanagisawa R., Inoue K., Kawazato H., Yasuda A., Hayakawa K. Int Arch Allergy Immunol, Vol.162(1), p7-15, 2013.

31.

The effects of (±)-Praeruptorin A on airway inflammation, remodeling and transforming growth factor-β1/Smad signaling pathway in a murine model of allergic asthma. Xiong Y, Wang J, Wu F, Li J, Kong L. International Immunopharmacology, Vol.14(4), p392-400, Dec 2012.

32.

Inhibitory effects of Drynaria fortunei extract on house dust mite antigen-induced atopic dermatitis in NC/Nga mice. Sung Y-Y, Kim D-S, Yang W-K, Nho K J, Seo H S, Kim Y S, Kim H K.. Journal of Ethnopharmacology, Vol.144(1), p94-100, Oct 2012.

33.

Topical application of an ethanol extract prepared from Illicium verum suppresses atopic dermatitis in NC/Nga mice. Sung Y-Y, Yang W-K, Lee A Y, Kim D-S, Nho K J, Kim Y S, Kim H K.. Journal of Ethnopharmacology, Vol.144(1), p151-159, Oct 2012.

34.

Anti-allergic effect of lactic acid bacteria isolated from seed mash used for brewing sake is not dependent on the total IgE levels. Masuda Y, Takahashi T, Yoshida K, Nishitani Y, Mizuno M, Mizoguchi H. Journal of Bioscience and Bioengineering, Vol.114(3), p292-296, Sep 2012.

35.

Advantages of histamine H4 receptor antagonist usage with H1 receptor antagonist for the treatment of murine allergic contact dermatitis. Matsushita A, Seike M, Okawa H, Kadawaki Y, Ohtsu H. Experimental Dermatology, Vol.21(9), p714-715, Sep 2012.

36.

Platycodon grandiflorus alleviates DNCB-induced atopy-like dermatitis in NC/Nga mice. Park S-J, Lee H-A, Kim J W, Lee B-S and Kim E-J. Indian J Pharmacol. Vol.44(4), p469-474, Jul-Aug 2012.

37.

Effect of Chrysanthemi borealis flos on atopic dermatitis induced by 1-chloro 2,4-dinitrobenzene in NC/Nga mouse. Yang G, Lee K, An D-G, Lee M-H, Ham I-H, Choi H-Y. Immunopharmacology and Immunotoxicology, Vol.34(3), p413-418, Jun 2012.

38.

Effects of (±)-praeruptorin A on airway inflammation, airway hyperresponsiveness and NF-κB signaling pathway in a mouse model of allergic airway disease. Xiong Y, Wang J, Wu F, Li J, Zhou L, Kong L. European Journal of Pharmacology, Vol.683(1-3), p316-324, May 2012.

39.

Anti-allergic effect of lactic acid bacteria isolated from seed mash used for brewing sake is not dependent on the total IgE levels. Y. Masuda., T. Takahashi., K. Yoshida., Y. Nishitani., M. Mizuno., H. Mizoguchi. Journal of Bioscience and Bioengineering, 2012.

40.

The Protective and Recovery Effects of Fish Oil Supplementation on Cedar Pollen-Induced Allergic Reactions in Mice. Hirao A, Furutani N, Nagahama H, Itokawa M, Shibata S. Food and Nutrition Sciences, Vol.3, p40-47, 2012.

41.

Th17-cells in atopic dermatitis stimulate orthodontic root resorption. Yamada K, Yamaguchi M, Asano M, Fujita S, Kobayashi R, Kasai K. Oral Diseases, 2012.

42.

Mixture of Polyphenols and Anthocyanins from Vaccinium uliginosum L. Alleviates DNCB-Induced Atopic Dermatitis in NC/Nga Mice. Kim M J and Choung S-Y. Evidence-Based Complementary and Alternative Medicine, Vol.2012 (2012)

43.

Single systemic administration of Ag85B of mycobacteria DNA inhibits allergic airway inflammation in a mouse model of asthma. Karamatsu K, Matsuo K, Inada H, Tsujimura Y, Shiogama Y, Matsubara A, Kawano M and Yasutomi Y. J Asthma Allergy, Vol.5, p71-79, 2012.

44.

Inhibitory Effect of Nelumbo nucifera (Gaertn.) on the Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice. R. Karki., M.-A Jung., K.-J. Kim., and D.-W Kim. Evidence-Based Complementary and Alternative Medicine, Vol. 2012 (2012), Article ID 153568, 7 pages

45.

Lack of Transient Receptor Potential Vanilloid-1 Enhances Th2-Biased Immune Response of the Airways in Mice Receiving Intranasal, but Not Intraperitoneal, Sensitization. T. Mori., K. Saito., Y. Ohki., H. Arakawa., M. Tominaga., K. Tokuyama. Int Arch Allergy Immunol 2011, Vol.156, p305-312.

46.

Improvement of the Antiinflammatory and Antiallergic Activity of Bidens pilosa L. var. radiata SCHERFF Treated with Enzyme (Cellulosine). Horiuchi, M. and Seyama, Y. Journal of Health Science, Vol. 54(2008), No.3, p294-301.

47.

Suppression of spontaneous dermatitis in NC/Nga murine model by PG102 isolated from Actinidia arguta. Park, E.J., Park, K.C., Eo, H, Seo, J., Son, M., Kim, K.H. et al. J Investigative Dermatology, Vol.127, p1154-1160, 2007.

48.

Sopungyangjae-Tang inhibits development of dermatitis in Nc/Nga mice. Pokharel, Y.R., Lim, S.C., Kim, S.C., Heo, T.H., Choi, H.K. and Kang, K.W. Evidence-based Complementary and Alternative Medicine nem015, 1-8, March 12, 2007.

49.

Inhibitory effect of DA-9201, an extract of Oryza sativa L., on airway inflammation and bronchial hyperresponsiveness in mouse asthma model. Lee, S.H., Sohm, Y.S., Kang, K.K., Kwon, J.W. and Yoo, M. Biol. Pharm. Bull. Vol.29(6), p1148-1153, 2006.

50.

A new symbiotic, Lactobacillus casei subsp. casei together with dextran, reduces murine and human allergic reaction. Ogawa, T., Hashikawa, S., Asai, Y., Sakamoto, H., Yasuda, K., and Makimura, Y. FEMS Immunology and Medical Microbiology, Vol.46, p400-409, 2006.

51.

Effects of alpha tocopherol and probucol supplements on allergen-induced airway inflammation and hyperresponsiveness in a mouse model of allergic asthma. Okamoto, N., Murata, T., Tamai, H., Tanaka, H., and Nagai, H. Int. Allergy Immunol. Vol.141, p172-180, 2006.

52.

Control of IgE and selective TH1 and TH2 cytokines by PG102 isolated from Actinidia arguta. Parkm E.J., Kim, B., Eo, H., Park, K, Kim, Y., Lee, H.J. and Son, M. J Allergy and Clinical Immunol, p1151-1167, 2005.

53.

Oral immunotherapy against a pollen allergy using a seed-based peptide vaccine. Takagi, H., Saito, S., Yang, L., Nagasawa, S., Nishizawa, N., and Takaiwa, F. Plant Biotechnology Journal, Vol.3, p521-533, 2005.

54.

Activated protein C inhibits bronchial hyperresponsiveness and Th2 cytokine expression in mice. Hisamichi Yuda, Yukihiko Adachi, Osamu Taguchi, Esteban C. Gabazza, Osamu Hataji, Hajime Fujimoto, Shigenori Tamaki, Kimiaki Nishikubo, Kenji Fukudome, Corina N. D’Alessandro-Gabazza, Junko Maruyama, Masahiko Izumizaki, Michiko Iwase, Ikuo Homma, Ryo Inoue, Haruhiko Kamada, Tatsuya Hayashi, Michael Kasper, Bart N. Lambrecht, Peter J. Barnes, and Koji Suzuki. Blood, Vol.103, No.6, p2196-2204, 2004.

55.

Inadequate induction of suppressor of cytokine signaling-1 causes systemic autoimmune diseases. Fujimoto, M., Tsutsui, H., Xinshou, O., Tokumoto, M., Watanabe, D., Shima, Y., Yoshimoto, T., Hirakata, H., Kawase, I., Nakanishi, K., Kishimoto, T., and Naka, T. International Immunology Vol.16, p303-314, 2004.

56.

Association of cathepsin E deficiency with development of atopic dermatitis. Tsukuba, T., Okamoto, K., Okamoto, Y., Yanagawa, M. J Biochemistry, Vol.134, p893-902, 2003.

57.

Mast-cell-dependent histamine release after praziquantel treatment of Schistosoma japonicum infection: implications for chemotherapy-related adverse effects. Jun Matsumoto and Hajime Matsuda. Parasitology Research, Vol.88, p888 – 893, 2002.

1.

Transgenic rat model of childhood-onset dermatitis by overexpressing telomerase reverse transcriptase (TERT). Ryosuke Kaneko, Atsuko Sato, Shun Hamada, Takeshi Yagi, Ichiro Ohsawa, Mamitaro Ohtsuki, Eiji Kobayashi, Masumi Hirabayashi, Takashi Murakami. Transgenic Research, pp 1-12, First online: 17 February 2016

2.

Oral administration of drugs with hypersensitivity potential induces germinal center hyperplasia in secondary lymphoid organ/tissue in Brown Norway rats, and this histological lesion is a promising candidate as a predictive biomarker for drug hypersensitivity occurrence in humans. A.Tamura, I.Miyawaki, T.Yamada, J.Kimura, H.Funabashi. Toxicology and Applied Pharmacology, Vol.271(1), p30-40, Aug 2013.

3.

Enhancement of the pulmonary allergic granulocyte recruitment in rats exposed to DMTI-Ⅱ,a Kunitz-type inhibitor isolated from Dimorphandra mollis seeds. Glaucia,C,M.,Karina,F,R.,Dalize,M,S.,Andre,A,S.,Ivani,A,de S.,Maria,L R,M.,Edson,A.. International Immunopharmacology, Vol.11(6),  p740-747, Jun 2011.

4.

Altered cytokine expression in mesenteric lymph nodes in a rat strain (Matsumoto Eosinophilic Shinshyu) that spontaneously develops hypereosinophilia. Muto, S., Monnai, M., Okuhara, Y., Murakami, M., Kuroda, J., Ono, T., and Matsumoto, K.. Immunology, Vol.116, p373-380, 2005.

 1.

Dysbiosis Contributes to Arthritis Development via Activation of Autoreactive T Cells in the Intestine. Maeda Y, Kurakawa T, Umemoto E, Motooka D, Ito Y, Gotoh K, Hirota K, Matsushita M, Furuta Y, Narazaki M, Sakaguchi N, Kayama H, Nakamura S, Iida T, Saeki Y, Kumanogoh A, Sakaguchi S, Takeda K. Arthritis Rheumatol. 2016 Nov;68(11):2646-2661.

 2.

C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production, and glomerulonephropathy in mice. Atanasio A, Decman V, White D, Ramos M, Ikiz B, Lee HC, Siao CJ, Brydges S, LaRosa E, Bai Y, Fury W, Burfeind P, Zamfirova R, Warshaw G, Orengo J, Oyejide A, Fralish M, Auerbach W, Poueymirou W, Freudenberg J, Gong G, Zambrowicz B, Valenzuela D, Yancopoulos G, Murphy A, Thurston G, Lai KM. Sci Rep. 2016 Mar 16

 3.

Reciprocal effects of Schistosoma mansoni infection on spontaneous autoimmune arthritis in IL-1 receptor antagonist-deficient mice. Osada Y, Yamada S, Nakae S, Sudo K, Kanazawa T. Parasitol Int. Vol.64(1), p13-17. Feb 2015.

 4.

The development of mixed cryoglobulinemia in Capillaria hepatica-infected mice is associated with the capillaria antigen-induced selective proliferation of splenic B-1a cells in response to interleukin-5 stimulation. Aihara N, Kamiie J, Yamada M, Shirota K. Am J Pathol. Vol.185(1), p172-84, Jan 2015.

 5.

Mechanism of the 24-hour rhythm of tumor necrosis factor-alpha formed by onset of rheumatoid arthritis. Yoshimatsu H., Okazaki F., Ieiri I., To H. Chronobiology International, 2014.

 6.

Deficient Leptin Signaling Ameliorates Systemic Lupus Erythematosus Lesions in MRL/Mp-Faslpr Mice. Fujita Y., Fujii T., Mimori T., Sato T., Nakamura T., Iwao H., Nakajima A., Miki M., Sakai T., Kawanami T., Tanaka M., Masaki Y., Fukushima T., Okazaki T. and Umehara H. The Journal of Immunology, Vol.192(3), p979-984, Feb 2014.

 7.

Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcγRIIB-deficient C57BL/6 mice. Kawano S, Lin Q, Amano H, Kaneko T, Nishikawa K, Tsurui H, Tada N, Nishimura H, Takai T, Shirai T, Takasaki Y, Hirose S. European Journal of Immunology, Vol.43(3), p770-778, Mar 2013.

 8.

IFN-γ-Producing Effector CD8 T Lymphocytes Cause Immune Glomerular Injury by Recognizing Antigen Presented as Immune Complex on Target Tissue. Tsumiyama K., Hashiramoto A., Takimoto M., Tsuji-Kawahara S., Miyazawa M. and Shiozawa S. The Journal of ImmunologyJuly, Vol.191(1), p91-96, 2013.

 9.

Increased expression of soluble form of vascular cell adhesion molecule-1 aggravates autoimmune arthritis in MRL-Fasipr mice. Oishi, H., Mizuki, S., Terada, M., Kudo, M., Araki, K., Araki, M., Nose, M., and Takahashi, S. Pathology International, Vol.57, p734-740, 2007.

10.

Electro-acupuncture at acupoint ST36 reduces inflammation and regulates immune activity in collagen-induced arthritic mice. Yim, Y.Y., Lee, H., Hong, K.E., Kim, Y.I., Lee, B.R., Son, C.G., and Kim, J.E. Evidence-based Complementary and Alternative Medicine 4:p51-57, 2007.

11.

Requirement for CD100-CD72 interactions in fine-tuning of B-cell antigen receptor signaling and homeostatic maintenance of the B-cell compartment. Kumanogoh, A., Shikina, T., Watanabe, C., Takegahara, N., Suzuki, K., Yamamoto, M., Takamatsu, H., Prasad, D.V.R., Mizui, M., Toyohuku, T., Tamaru, M., Watanabe, D., Parnes, J.R., and Kikutani, H. International Immuno, Vol.17, p1277-1282, 2005.

12.

The point mutation of tyrosine 759 of the IL-6 family cytokine receptor gp130 synergizes with HTLV-1 pX in promoting rheumatoid arthritis-like arthritis. Ishihara, K., Sawa, S., Ikushima, H., Hirota, S., Atsumi, T., Kamimura, D., Park, S.J., Murakami, M., Kitanuma, Y., Iwakura, Y., and Hirano, T. International Immunol. Vol.16, p455-465, 2004.

13.

Chemical induction of HO-1 suppresses lupus nephritis by reducing local iNOS expression and synthesis of anti-dsDNA antibody. Takeda, Y., Takeno, M., Iwasaki, M., Kobayashi, H., Kirino, Y., Ueda, A., Nagahama, K., Aoki, I., and Ishigatsubo, Y. Clin Exp Immunol. Vol.138, p237-244, 2004.

14.

A Point Mutation of Tyr-759 in Interleukin 6 Family Cytokine Receptor Subunit gp130 Causes Autoimmune Arthritis. T. Atsumi., K. Ishihara., D. Kamimura., H. Ikushima., T. Ohtani., S. Hirota., H. Kobayashi., S. Park., Y. Saeki., Y. Kitamura. and T. Hirano. J Exp Med, 196, Number 7, p979-990, 2002.

15.

A novel assay kits for autoantibodies rate on spontaneous autoimmune model mice. Kikukawa, T, Kojima, M., and Abe, C. Jap J Inflammation, Vol.20, p697-701, 2000.

 1.

C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production, and glomerulonephropathy in mice.
Atanasio A, Decman V, White D, Ramos M, Ikiz B, Lee HC, Siao CJ, Brydges S, LaRosa E, Bai Y, Fury W, Burfeind P, Zamfirova R, Warshaw G, Orengo J, Oyejide A, Fralish M, Auerbach W, Poueymirou W, Freudenberg J, Gong G, Zambrowicz B, Valenzuela D, Yancopoulos G, Murphy A, Thurston G, Lai KM.

Sci Rep. 2016 Mar 16

 2.

Production of Autoantibodies by Murine B-1a Cells Stimulated with Helicobacter pylori Urease through Toll-Like Receptor 2 Signaling
Kobayashi F, Watanabe E, Nakagawa Y, Yamanishi S, Norose Y, Fukunaga Y and Takahashi H.

Infect. Immun, Vol.79(12), p4791-4801, Dec 2011.

 3.

Lack of B and T lymphocyte attenuator exacerbates autoimmune disorders and induces Fas-independent liver injury in MRL-lpr/lpr mice
Y. Oya., N. Watanabe. Y. Kobayashi., T. Owada., M. Oki., K. Ikeda. A. Suto., S. Kagami., K. Hirose., T. Kishimoto., and H. Nakajima.

Int. Immunol. Vol.23(5), p335-344, 2011.

 4.

An experimental type 2 mixed cryoglobulinemia with renal glomerulopathy in ICR mice triggered by Capillaria hepatica infection
N. Aihara., J. K. Chambers., K. Hosono., J. Kamiie., and K. Shirota.

Histol Histopathol, Vol.26, p1519-1529, 2011.

 5.

Point mutation of tyrosine 759 of the IL-6 family cytokine receptor,gp130,augments collagen-induced arthritis in DBA/IJ mice
Tsuji,F.,Yoshimi,M.,Katsuta,O.,Takai,M.,Ishihara,K.,Aono,H.

BMC Musculoskeletal Disorders ,10:23, 2009.

 6.

Implications for induction of autoimmunity via activation of B-1 cells by Helicobacter pylori urease.
Yamasnishi, S., Iizumi, T., Watanabe, E., Shimizu, M., Kamiya, S., Nagata, K., Kumagai, Y., Fukunaga, Y., and Takahashi, H.

Infection and Immunity, Vol.74, p248-256, 2006.

 7.

Cytokine production profile of splenocytes derived from zymosan A-treated SKG mice developing arthritis.
Kobayashi, K., Suda, T., Nan-ya, K., Sakaguchi, N., Sakaguchi, S., and Miki, I.

Inflammation Research, Vol.55, p335-341, 2006.

 8.

Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages.
Kawane, K., Ohtani, M., Miwa, K., Kizawa, T., Kanbara, Y., Yoshioka, Y., and Yoshikawa,H.

Nature, Vol.443, p998-1002, 2006.

 9.

Requirement for CD100-CD72 interactions in fine-tuning of B-cell antigen receptor signaling and homeostatic maintenance of the B-cell compartment.
Kumanogoh, A., Shikina, T., Watanabe, C., Takegahara, N., Suzuki, K., Yamamoto, M., Takamatsu, H., Prasad, D.V.R., Mizui, M., Toyohuku, T., Tamaru, M., Watanabe, D., Parnes, J.R., and Kikutani, H.

International Immuno, Vol.17, p1277-1282, 2005.

10.

A Point Mutation of Tyr-759 in Interleukin 6 Family Cytokine Receptor Subunit gp130 Causes Autoimmune Arthritis
T. Atsumi., K. Ishihara., D. Kamimura., H. Ikushima., T. Ohtani., S. Hirota., H. Kobayashi., S. Park., Y. Saeki., Y. Kitamura. and T. Hirano

J Exp Med, 196, Number 7, p979-990, 2002.

11.

A novel assay kits for autoantibodies rate on spontaneous autoimmune model mice.
Kikukawa, T, Kojima, M., and Abe, C.

Jap J Inflammation, Vol.20, p697-701, 2000.

产品详情

别名

　Pycard; 甲基化诱导沉默的靶点1; TMS1; 

　Caspase Recruitment Domain-containing Protein 5; 

　细胞凋亡相关Speck样蛋白 CARD; CARD5

产品类型

　多克隆抗体

免疫动物/宿主

　兔

免疫原/抗原

　对应于N末端人Asc的氨基酸合成肽.

应用

　免疫细胞化学 (1:200)
　免疫组织化学: (1:500;   paraffin sections)
　免疫沉淀: (1:200)
　Western Blot: (1:1000)
　功能应用: (见参考文献  [1])

交叉反应性

　人，小鼠

特异性

　识别人和小鼠Asc.

纯度

　表位亲和纯化

浓度

　1mg/mL

配方

　液体，溶解在含有10％甘油和0.02％叠氮钠的PBS中

运输

　干冰

短时间

储存

　+4°C

长时间

储存

　-20°C

[1]

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder: L. Agostini,et al.; Immunity 20, 319 (2004)

[2]

P2X7 Receptor Differentially Couples to Distinct Release Pathways for IL-1beta in Mouse Macrophage: P. Pelegrin, et al.; J. Immunol. 180, 7147 (2008)

[3]

Inflammatory role of ASC in antigen-induced arthritis is independent of caspase-1, NALP-3, and IPAF: L. Kolly, et al.; J. Immunol. 183, 4003 (2009)

[4]

Activation of autophagy by inflammatory signals limits IL-1b production by targeting ubiquitinatedinflammasomes for destruction: C.-S. Shi, et al.; Nat. Immunol. 13, 255  (2012)

[5]

NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice: M.T. Heneka, et al.;  Nature 493, 674 (2013)

[6]

Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation: J.K. Dowling, et al.; J. Biol. Chem. 289, 6429 (2014)

[7]

Localization and functionality of the inflammasome in neutrophils: M. Bakele, et al.; J. Biol. Chem. 289, 5320      (2014)

[8]

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation: B.S. Franklin, et al.; Nat. Immunol. 15, 727 (2014)

[9]

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response: A. Baroja-Mazo, et al.; Nat. Immunol. 15, 738 (2014)

[10]

Aging-associated TNF production primes inflammasome activation and Nlrp3-related metabolic disturbances: F. Bauernfeind, et al.; J. Immunol. 197, 2900 (2016)

[11]

An Investigation of Inflammatory and Metabolic Blood-Based Biomarkers of Cognitive Decline: H. Wolfe; Thesis Univ. Dublin, Trinity College Dep. of Physiol. (2018)

名称

参数

SCG-030（型号）

SCG-100（型号）

泵

流速

36 ml/min (MAX.)

100 ml/min (MAX.)

流速精度

±2%

±2%

流速重复性

RSD<0.5%

RSD<0.5%

压力

RSD<0.5%

RSD<0.5%

梯度方式

二元高压

二元高压

检测器

检测器

200~600 nm

波长精度

±1   nm

波长重复性

±   0.5nm

噪声

±4   x 10-5 AU (1s)

漂移

1 x 10-3 AU/Hr

特点

实时4   波长输出

进样器

手动或自动进样阀（0.02~2.0 ml 定量环，可定制）

酸度/   电导检测器

酸度范围/精度

pH 0 ~ 14 / ±   0.02

电导范围/精度

0.001 ~ 999.9 mS/cm / ±2%

温度范围/精度

2 ~ 50℃   / ± 1℃