santacruz GSK-3 Inhibitor X
- 产品型号： SC-221689
- 简单描述
- santacruz GSK-3 Inhibitor X分子量: 398.2分子式: C18H12BrN3O3可溶性: Soluble in DMSO
详细介绍
santacruz GSK-3 Inhibitor X
santacruz GSK-3 Inhibitor X详细产品信息：
GSK-3 Inhibitor X (CAS 740841-15-0)
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| Synonym: |
BIO-Acetoxime; 6-Bromoindirubin-3′-acetoxime, BIA |
| Application: |
A selective GSK-3α/β inhibitor |
| CAS Number: |
740841-15-0 |
| Purity: |
≥95% |
| Molecular Weight: |
398.21 |
| Molecular Formula: |
C18H12BrN3O3 |
| Refer to Certificate of Analysis for lot specific data (including water content). |
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Ordering Information
| Product Name |
Catalog # |
Unit |
Price |
Qty |
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| GSK-3 Inhibitor X |
sc-221689 |
1 mg |
$115 |
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Description
GSK-3 Inhibitor X is an acetoxime analog of BIO which acts as a selective GSK-3α/β inhibitor (IC50 values are 0.01, 2.4, 4.3 and 63 μM for GSK-3α/β, CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). GSK-3 Inhibitor X induces Wnt signaling and inhibits CD8+ T cell effector differentiation.
Technical Information
| Physical State: |
Solid |
| Solubility: |
Soluble in DMSO (10 mg/ml). |
| Storage: |
Store at 4° C |
| Melting Point: |
236.83 °C (Predicted) |
| Boiling Point: |
551.87 °C (Predicted) |
| Density: |
1.69 g/cm3 (Predicted) |
| Refractive Index: |
n20D 1.74 (Predicted) |
| IC50: |
GSK-3α/β: IC50 = 10 nM; Cdk5/p25: IC50 = 2.4 µM; Cdk2/A: IC50 = 4.3 µM; Cdk1/B: IC50 = 63 µM; Cdk4/D1: IC50 = ≥10 µM; aryl hydrocarbon receptor: EC5050 = ≥0.1 µM (yeast); aryl hydrocarbon receptor: EC5050 = 0.16 µM (mammalian) |
| pK Values: |
pKa: 9.23 (Predicted) |
Safety and Reference Information
| PubChem CID: |
6538818 |
| MDL Number: |
MFCD09037533 |
| SMILES: |
CC(=O)ONC1=C2C=CC=CC2=NC1=C3C4=C(C=C(C=C4)Br)NC3=O |
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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