重组人类组蛋白 H3.1/H4 四聚体 货 号 #M2509SNEB酶试剂 New England Biolabs

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产品资料 – 表观遗传学 – 组蛋白

重组人类组蛋白 H3.1/H4 四聚体                              收藏

重组人类组蛋白 H3.1/H4 四聚体 货 号 #M2509S 重组人类组蛋白 H3.1/H4 四聚体 货 号 #M2509S

货 号
规 格
价 格(元)
北京库存
上海库存
广州库存
成都库存
苏州库存

#M2509S
1 nmol
3,019.00
无
无
无
无
无

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  • isoschizomers     |
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  • single letter code

Description:

 Histone H3.1 combines with Histone H4 to form the H3/H4 tetramer. Two H2A/H2B heterodimers interact with an H3/H4 tetramer to form the histone octamer. Histone H3.1, an H3 variant that has thus far only been found in mammals, is replication dependent and is associated with gene activation and gene silencing. The tetramer is also modified by various enzymes and can act as a substrate for them. These modifications have been shown to be important in gene regulation. Because the histones are folded with their subunit partners, the tetramer may be a better substrate for specific enzymes and modifications.

 
Human Histone H3.1 Protein Sequence: ARTKQ TARKS TGGKA PRKQL ATKAA RKSAP ATGGV KKPHR YRPGT VALRE IRRYQ KSTEL LIRKL PFQRL VREIA QDFKT DLRFQ SSAVM ALQEA CEAYL VGLFE DTNLC AIHAK RVTIM PKDIQ LARRI RGERA (Genbank accession number: AAN10051)
 
Human Histone H4 Protein Sequence: SGRGK GGKGL GKGGA KRHRK VLRDN IQGIT KPAIR RLARR GGVKR ISGLI YEETR GVLKV FLENV IRDAV TYTEH AKRKT VTAMD VVYAL KRQGR TLYGF GG (Genbank accession number: AAM83108)
重组人类组蛋白 H3.1/H4 四聚体 货 号 #M2509S

Source

 Purified H3.1 and H4 (NEB #M2503 and NEB #M2504) were denatured, refolded and the Histone H3/H4 Tetramer was purified by gel filtration

Properties and Usage

 Storage Temperature
-20°C

Storage Conditions

 

20 mM Tris-HCl 
2 M NaCl 
1 mM DTT 
1 mM EDTA 
pH 8.0 @ 25°C