产品编号

产品名称

中文名称

包装

备注

309-34133

Biostir^® AD

Biostir^®特应性皮炎诱导剂AD

5g

软膏包括来自粉尘螨的螨过敏原，-30℃

303-34131

Biostir^® AD

Biostir^®特应性皮炎诱导剂AD

15g

项目

方法

动物

特应性皮炎模型服务和药理学测试

1.在D粉尘螨具有高含量螨变应原的NC / Nga小　鼠中通过Biostir® AD诱导特应性皮炎样损伤。

2.经皮致敏/免疫小鼠。

3.高概率获得特应性皮炎模型。
4.评估测试物质对疾病模型的效力。
5.评价项目：

症状评分，IgE，组织病理学，搔抓行为等。

小鼠

（NC / Nga）

更多详情请咨询我司。

动物

雌性NC / Nga小鼠

特应性皮炎样皮肤损伤的临床方面

在皮肤上观察到搔抓行为，红斑，丘疹，鳞屑，疮痂和苔藓病变

组织学评价

损伤皮肤表现在真皮和表皮显著增厚，角化过度和角化不全。
在损伤小鼠中观察到包括肥大细胞和嗜酸性粒细胞在内的皮肤炎症细胞数量的增加。
损伤小鼠中总数和脱颗粒的肥大细胞的数量多于正常小鼠。

血清总IgE

显著升高

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Lee, J. K., Ha, H., Lee, H. Y., Park, S. J., Jeong, S. L., Choi, Y. J., & SHIN, H. K. (2010). Inhibitory effects of heartwood extracts of Broussonetia kazinoki Sieb on the development of atopic dermatitis in NC/Nga mice. Bioscience, biotechnology, and biochemistry, 1007282075-1007282075.

Lim, H. S., Ha, H., Lee, H., Lee, J. K., Lee, M. Y., & Shin, H. K. (2014). Morus alba L. suppresses the development of atopic dermatitis induced by the house dust mite in NC/Nga mice. BMC complementary and alternative medicine, 14(1), 139.

Aktar, M. K., Kido‐Nakahara, M., Furue, M., & Nakahara, T. (2015). Mutual upregulation of endothelin‐1 and IL‐25 in atopic dermatitis. Allergy, 70(7), 846-854.

Joo, S. S., Won, T. J., Nam, S. Y., Kim, Y. B., Lee, Y. C., Park, S. Y., … & Lee, D. I. (2009). Therapeutic advantages of medicinal herbs fermented with Lactobacillus plantarum, in topical application and its activities on atopic dermatitis. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 23(7), 913-919.

Lim, H. S., Seo, C. S., Ha, H., Lee, H., Lee, J. K., Lee, M. Y., & Shin, H. (2012). Effect of Alpinia katsumadai Hayata on house dust mite-induced atopic dermatitis in NC/Nga mice. Evidence-Based Complementary and Alternative Medicine, 2012.

Lim, H. S., Ha, H., Lee, M. Y., Jin, S. E., Jeong, S. J., Jeon, W. Y., … & Shin, H. K. (2014). Saussurea lappa alleviates inflammatory chemokine production in HaCaT cells and house dust mite-induced atopic-like dermatitis in Nc/Nga mice. Food and chemical toxicology, 63, 212-220.

Kim, M. C., Lee, C. H., & Yook, T. H. (2013). Effects of anti-inflammatory and Rehmanniae radix pharmacopuncture on atopic dermatitis in NC/Nga mice. Journal of acupuncture and meridian studies, 6(2), 98-109.

Lee, J. N., Lee, C. H., & Kim, Y. S. (2015). Protective effects of Opuntia humifusa cladode extracts against biostir AD-induced atopic dermatitis in NC/Nga mice. Food Science and Biotechnology, 24(3), 1123-1130.

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Lee, H., Ha, H., Lee, J. K., Seo, C. S., Lee, N. H., Jung, D. Y., … & Shin, H. K. (2012). The fruits of Cudrania tricuspidata suppress development of atopic dermatitis in NC/Nga mice. Phytotherapy Research, 26(4), 594-599.

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Ha, H., Lee, H., Seo, C. S., Lim, H. S., Lee, J. K., Lee, M. Y., & Shin, H. (2014). Artemisia capillaris inhibits atopic dermatitis-like skin lesions in Dermatophagoides farinae-sensitized Nc/Nga mice. BMC complementary and alternative medicine, 14(1), 100.

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Ignacio, R. M. C., Kwak, H. S., Yun, Y. U., Sajo, M., Yoon, Y. S., Kim, C. S., … & Lee, K. J. (2013). The drinking effect of hydrogen water on atopic dermatitis induced by Dermatophagoides farinae allergen in NC/Nga mice. Evidence-Based Complementary and Alternative Medicine, 2013.

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